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| #5,962,332 |
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Disclosed
is a method of detecting a trinucleotide repeat expansion by in situ hybridization.
The disclosed method uses a sample of nucleated cells, a labeled trinucleotide
repeat-specific probe and detection of the hybridized probe by a means
whose sensitivity distinguishes between the signal from probes hybridized
to an expanded repeat and the signal from probes hybridized to a non-expanded
repeat. |